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Sisu Clinic Opens Its Third NYC Location in the Upper East Side

Sisu Clinic Opens Its Third NYC Location in the Upper East Side
25 November 2025

We’re thrilled to announce the opening of our brand-new Sisu Clinic in the Upper East Side, right on Lexington Avenue—a move that marks a major milestone for us. This is now our third clinic in New York City, our seventh location in the United States, and our 27th clinic worldwide. For us at Sisu, this expansion isn’t just about growing—it’s about being exactly where our patients need us most.

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Why We Chose the Upper East Side

The Upper East Side is iconic for a reason. Refined, elegant, and full of possibility, this neighbourhood mirrors everything Sisu Clinic stands for: quality, authenticity, and a commitment to results that feel natural and empowering.

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A Doctor-Led Clinic Offering NYC’s Most Trusted Aesthetic Treatments


As a doctor-led aesthetic clinic, Sisu is known for safe, results-driven treatments backed by medical expertise and exceptional patient care. Our Upper East Side location offers the full suite of Sisu favourites, including:

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Botox™:Dysport™ NYC – Smooth, Refresh, and Rejuvenate


If you’re searching for Botox NYC or Botox Upper East Side, Sisu Clinic is one of the most trusted names in the city. Our medical providers specialise in natural-looking wrinkle smoothing using Botox™:Dysport™, helping soften fine lines while preserving your natural expression.

Popular Botox treatment areas:

  • 3 areas Botox™:Dysport™ - Forehead lines, Frown/“11” lines, Crow’s feet
  • Bunny lines
  • Masseter slimming
  • Brow lift
  • Lip flip
  • TrapTox Treatment (Trapezius Botox)
  • Hyperhidrosis Treatment (Botox for excessive sweating)

With thousands of 5-star Google reviews across our global clinics, patients consistently choose Sisu for Botox because our approach is always customised, conservative, and aligned with your unique facial anatomy.

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Dermal Fillers – Lift, Shape & Restore Volume


Our team offers advanced filler treatments designed to restore youthful volume, enhance your features, and balance facial proportions. Whether you’re seeking subtle lip hydration or a refreshed mid-face, our injectors use premium hyaluronic acid fillers to achieve a natural, lifted look.

Popular filler treatments at Sisu Upper East Side:

  • Cheek filler for lift and contour
  • Under-eye filler for tired-looking eyes
  • Lip filler for shape and subtle volume
  • Chin and jawline filler for improved definition
  • Nasolabial and marionette line support
  • Non-Surgical Rhinoplasty - Subtle nose reshaping using dermal fillers — improve the bridge, lift the tip, or correct small bumps without surgery.

Each treatment is tailored to create results that blend seamlessly with your features — never overdone.

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Microneedling With REJURAN – The Viral “Glass Skin” Treatment Loved by Celebrities

If you've been scrolling TikTok lately, you’ve definitely seen this treatment — the viral “salmon skin” rejuvenation trend, adored for its ability to deliver dewy, poreless, glass-like skin. Now available at Sisu Clinic Upper East Side, our Microneedling with REJURAN treatment is one of the most powerful complexion-transforming procedures in NYC.

This is the same type of treatment that A-listers like Kim Kardashian and Jennifer Aniston have been rumoured to use to maintain their glowing, youthful skin. The magic comes from polynucleotides derived from salmon DNA, which repair, hydrate and regenerate the skin at a cellular level.

What It Does:

  • Delivers deep, long-lasting hydration
  • Smooths texture and refines pores
  • Brightens dull skin
  • Boosts elasticity
  • Softens fine lines
  • Creates that “glass skin” finish

By combining collagen-inducing microneedling with REJURAN’s restorative formula, we offer one of NYC’s most effective treatments for overall skin glow, firmness, and youthful radiance — now available right here in the Upper East Side.

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Sculptra – Long-Term Collagen Support

Sculptra is a powerful, regenerative treatment designed for gradual, long-lasting rejuvenation. It stimulates your body’s collagen production to improve volume, support facial structure, and smooth fine lines over time. Ideal for patients who want subtle, progressive and extremely natural results.

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BBL Sculptra® (Non-Surgical Butt Lift)

Now available at our Upper East Side location, BBL Sculptra® is a non-surgical option for:

  • Enhancing curve and projection
  • Improving hip dips
  • Lifting the buttocks naturally
  • Smoothing skin texture and cellulite appearance

This treatment is ideal for those seeking subtle enhancement without implants or surgery.

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Why NYC Patients Love Sisu Clinic

Doctor-Led Expertise

Your treatments are delivered by medical professionals trained to prioritise safety, anatomy and results.

Transparent Pricing

We’re known for clear, upfront pricing with no surprise add-ons.

Global Reputation

With 27 clinics worldwide, Sisu has earned thousands of 5-star reviews from satisfied patients.

Natural, Refreshing Results

Our philosophy is simple: enhance what’s already there — not change who you are.

A Beautiful, Comfortable Space

The Upper East Side clinic reflects everything our brand stands for: calm, refined, modern and welcoming.

Your New Go-To For Botox™:Dysport™, Fillers & Skin Treatments in the Upper East Side

Opening this clinic is more than a milestone — it’s a commitment. A commitment to being closer to you, to making expert aesthetic care easier to access, and to serving a neighbourhood that truly values quality.

We can’t wait for you to step inside our new Lexington Avenue clinic, explore our range of treatments, and begin your journey to refreshed, confident, glowing skin.

Whether you’re searching for Botox NYC, Botox Upper East Side, filler specialists NYC, Rejuran NYC, or Sculptra Upper East Side, Sisu Clinic is now right here in your neighbourhood.

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Come Visit Us on Lexington Avenue

Drop in, say hello, and let our team guide you toward the best version of yourself — naturally.

See you soon at Sisu Clinic Upper East Side.

Frequently Asked Questions

What treatments are available at Sisu Clinic Upper East Side?

Our Upper East Side clinic offers the full Sisu treatment menu, including Botox and Dysport for forehead lines, frown lines, and crow's feet; dermal fillers for lips, cheeks, and under-eyes; masseter Botox for jaw slimming and teeth grinding; Sculptra; Rejuran microneedling; and Kybella for chin fat reduction. Free consultations are included with every appointment, and our flat $495 pricing for three areas of Botox applies here just as it does across all our NYC locations.

Where exactly is the Sisu Clinic Upper East Side located?

We're on Lexington Avenue in the Upper East Side, easily accessible from Lenox Hill, Carnegie Hill, and the surrounding neighbourhood. The Upper East Side clinic is our third New York City location, joining our clinics in SoHo and the Flatiron District.

Does the Upper East Side clinic offer same-day or same-week appointments?

Yes — we aim to offer flexible booking across all our NYC locations. You can book online through our website, and same-week appointments are typically available. A free consultation is included with your first visit so your provider can assess your goals and create a personalised treatment plan before any treatment begins.

Is Sisu Clinic Upper East Side doctor-led?

Yes. Sisu Clinic is a doctor-founded, doctor-led aesthetic brand. All our providers are rigorously trained and work within a medically supervised framework across every location, including the Upper East Side. We were founded by two doctors with a focus on safety, natural results, and transparent pricing — no upsells, no hidden fees

What makes Sisu Clinic different from other Botox clinics on the Upper East Side?

A few things stand out: our flat-fee pricing model ($495 for three areas of Botox with a fourth area free) means you know exactly what you're paying before you arrive. Every treatment includes a free consultation and a complimentary 2-week dosage review. And as a doctor-led clinic with over 15K+ five-star reviews across all our Sisu locations, our focus is always on natural, balanced results — not on upselling.

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